Home Improvement Ideas: Home Improvement Ideas - Trendy Door ...

When looking for new home improvement ideas, many homeowners revert back to the classic ideas. Although purchasing a new couch or a new dining room table will certainly make a difference to the look of your home, this could be an extremely costly and time consuming process if it's not completely necessary. If you want to update the look and feel of your home quickly and easily, there are tons of solutions available to you. Many homeowners forget about the details that lie within every single room of their home. Although you may not notice them now, by paying a little extra attention, you can add some interesting and exciting detail into a room that will completely update your d?cor.

One major aspect of our homes that we often overlook is the doors. Doors give the first impression to not only your home itself, but every other room inside of it. In order to see the carefully planned design of your room, a visitor must first see the door that hides it. Considering the addition of new door hardware can give your rooms a new and updated look. Not only will the installation of new door hardware pull together the look and feel of your room itself, by coordinating small details like these, you'll be giving your entire home a coordinated vibe.

New door handles are a great place to start. If you're looking to give your home a trendier feel, playing with interesting door handle ideas could be just the solution you need. With hundreds of styles, colors, and materials available to you, you can find a door handle for any style home. Whether you are interested in achieving that trendy look within your home, or you're just looking to add a little extra detail to your doors - new door hardware can make the impact that you desire.

Another great option is replacing current, round door handles with door levers. Not only do these give off a more modern and more sophisticated feel, they could be the small detail your room needs to give it that updated and pulled together look. Even if you're not a home improvement expert, home renovation doesn't have to come strictly with large, time consuming projects. Installing new door hardware could be the perfect option for you if you're interested in testing the waters of home renovation. With the requirement of very few tools and little to no clean up time, installing new door handles or door levers gives you the opportunity to make a change to your home without having to call upon costly outside labor.

If you considering replacing your doors altogether, settling for boring door hardware is like getting a brand new dining room table, and then covering it in an old, unsightly tablecloth. By complimenting new pieces within your home by focusing in on their details, you'll be able to accomplish and pulled together, trendy look within your home. By installing new door handles on your new door, you'll be making an already great piece even greater.

Regardless of whether you're considering redoing an entire room, or just looking for interesting new home improvement ideas to implement into your space, door hardware is the perfect finishing touch on any project. As previously mentioned, the door is the ultimate first impression on any space. Even if your room is beautifully designed, if your door hardware isn't on point - your amazing d?cor could be hindered by this small detail. By taking doors into consideration when updating the look of your home, you can be sure that you will achieve a finished and pulled together look worth showing off.

Article Source: http://EzineArticles.com/2112292

Source: http://redlighteagle.blogspot.com/2012/10/home-improvement-ideas-trendy-door.html

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Get more fresh vegetables in your diet - Dish Magazine iPad

Cooking healthy is not a compromise in terms of food taste. It is important to know which the proper foods combinations and tastes are and this way you will discover a wide variety of dishes that you can prepare easily and cheaply. To cook healthy does not mean depriving you of taste and flavoursome food. Just adding healthy ingredients, spices and herbs to your diet will dramatically benefit to your health.

To cook healthy foods does not mean that all your must be raw or all the meals should be made only from vegetables and fruits. Healthy foods should be a combination of vitamins, minerals and antioxidants, whether boiled or prepared in the oven. Use fresh ingredients when cooking and try to choose those natural products without chemicals. Try not to overcook vegetables and fruits, because they can lose a lot of nutrients in the process ? when boiling vegetables, boil them 5 minutes and then soak them another 5 minutes in cold water to stop the cooking process.

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Work just beginning as drugmakers put Nobel discoveries to test

By Julie Steenhuysen and Ben Hirschler

CHICAGO/LONDON | Thu Oct 11, 2012 1:17am EDT

CHICAGO/LONDON (Reuters) - For some scientists, winning a Nobel Prize marks the end of a long and successful career.

But the work, in a sense, is just beginning for newly minted Nobel laureates in chemistry Dr. Brian Kobilka, 57, of Stanford University in California, and his mentor, Dr. Robert Lefkowitz, 69, of Duke University Medical Center in Durham, North Carolina.

"There is still a lot to do," Kobilka said in a telephone interview from his home in Palo Alto, California, where he learned of his prize early on Wednesday morning. "There is a lot to do."

In research spanning four decades, the scientists working separately and together have helped to characterize the exact structure of an important class of proteins known as G-protein-coupled receptors or GPCRs, which serve as a main conduit for chemicals to get past a cell's membrane and be taken up by a cell.

Roughly 1,000 human genes carry genetic codes for the receptors, which affect a variety of functions, from the beating of the heart to the workings of the brain and even how cells in the nose detect odors.

A subset of these receptors, some several hundred, respond to hormones and neurotransmitters in the body, and these have been targets for drug discovery, in many cases even before researchers knew these receptors existed.

About 40 percent of drugs already use these receptors or doors to get inside of cells, including Eli Lilly's antipsychotic drug Zyprexa and Bristol-Myers' diabetes treatment Byetta.

The problem is that drugs often act on more than one receptor, and so they have side effects.

"We hope the more we know about the structure of these proteins, the more we'll be able to develop safer, more effective drugs," Kobilka said in the interview.

Lefkowitz set out in the 1970s to prove these receptors existed, and that they could be studied, cloned and manipulated to develop new drugs.

Kobilka, who worked in Lefkowitz's lab in the 1980s, extended that research by helping to define the exact crystal structure of every atom of these receptors at a molecular level, something that had eluded researchers.

"Their findings have shone a light onto the staggeringly complex world of how hormones, neurotransmitters and drugs control cellular function and opened the door to the development of new therapeutics with potential to treat a vast array of diseases," said Bernadette Byrne of Imperial College London.

This is what people have been awaiting for years, said longtime drug researcher Sid Topiol, chief scientific officer of New Jersey-based computer-aided drug design company 3D-2Drug.

"Far and away, the most significant class of drug proteins are these GPR-coupled receptors," said Topiol, adding that Kobilka's work characterizing the structure of these proteins in 3D "opened up a watershed of new opportunities for drug discovery."

LOCK AND KEY

Topiol, who has been in the early stages of drug design for the past three decades, said people traditionally talk about drugs using a lock and key model.

"The drug is the key, and you are designing it to be a perfect match for the lock you are interested in," he said.

But while researchers had detailed information about the keys, for years there was nothing known about the lock itself. Now researchers are using Kobilka's discoveries to precisely characterize the structure of those GPCR locks.

"There are now 14 or 15 published GPCR structures, several from Kobilka's laboratory, and new drugs are being designed using the new knowledge of GPCR structure and function that will eventually improve medical treatments," said Richard Henderson of the University of Cambridge.

Fiona Marshall, founder and chief scientific officer at British-based Heptares, a private drug company that specializes in GPCRs, said many of the drugs that currently target these proteins - beta-blockers, antihistamines and atypical antipsychotics for schizophrenia - represent the low-hanging fruit.

She sees lots of potential to develop new medicines as well as making more targeted versions of existing treatments with fewer side effects.

"The breakthroughs that the Nobel Prize relates to is understanding the structure of the proteins at the molecular level," she said.

"That means you can actually design a compound using knowledge of the protein structure, which should result in much better and safer medicines that are more specific to the target," she said.

Heptares, which has done drug development deals with large drugmakers including AstraZeneca, Takeda, Novartis and Shire, is working on one of the first drug candidates to be developed using the new protein structures, which have been characterized in the past few years.

The drug, a molecule that the company is developing in partnership with Shire, targets neurological diseases and could enter clinical trials as early as next year.

Other illnesses that might benefit from these discoveries include Alzheimer's, schizophrenia and metabolic diseases such as diabetes.

Marshall said she thinks companies could develop better drugs using these discoveries.

"A lot of existing drugs that target GPCRs could be improved on because they often hit multiple different GPCRs and therefore have side effects. For example, atypical antipsychotics hit around a dozen GPCRs, whereas probably only one or two are important for the therapeutic effect," she said, noting that the other ones cause weight gain and sedation.

(Editing by Xavier Briand)

Source: http://feeds.reuters.com/~r/reuters/scienceNews/~3/EXSILleT2ms/us-nobel-chemistry-drugs-idUSBRE8991LI20121011

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The other big debate: O'Reilly vs. Stewart (CNN)

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Account Executive Job available at VirtualStudio.TV in Cambridge ...

Account ExecutiveJob available at VirtualStudio.TV in Cambridge

We?re on the lookout for a bright and motivated Account Executive to swell the ranks of the Virtual Studio team.?

?

You?ll get to work on real projects from day one in this role - you?ll handle clients, help organise video shoots and virtual events as well as manage our Social Media presence. If we do say so ourselves, it?s a brilliant opportunity for someone who is itching to get started in the industry.

About Us

We are an innovative, fast-growing and ambitious company that has developed a new way of producing and streaming videos and virtual events. We want to add a new member to the team as we look to expand the business further in 2013. If you have a passion for video production and are hankering to kick-start a career in the industry then please read on dear reader?

About your role

If a placid kind of office role where the days tick over at a sloth-like pace is what you?re looking for, then we have to be honest and say up front that this is not the role for you! This is a lively position in a rapidly growing company, and we?re after someone who will relish the fact that no two days are ever the same.

From day one you?ll be working with our most valuable asset: our clients. We regularly work with major international and FTSE 100 companies, and it will be your job to identify and anticipate their communication needs and help them to convey their messages in an effective way. You?ll help to develop creative video solutions, and ensure that production and delivery is a smooth and organised process from start to finish. You?ll act as our client?s go-to person and ideally you?ll have customer handling experience and a passion for media production.? You?ll also need a hawk?s eye for detail and hands on experience of working with Microsoft programmes and the main social media platforms. You?ll be based in our Cambridge studio but there may be the occasional client visit or location shoot you?ll need to go to, so bear in mind the odd spot of travel may be needed.

The starting salary will be between ?16,500 and ?18,500 depending on experience.

Your responsibilities will include:

? Liaising with clients to organise scripts and supporting material for use in video and virtual event productions.

? Assisting with producing the content needed to create a successful video: preparation of shoot schedules, call sheets and sourcing relevant pictures, sound and video files.

? Managing the company calendar and organising shoot times.

? Managing our YouTube, Facebook, Twitter and LinkedIn pages ? you?ll become a recognised face of the company

About You

? You have excellent communication and writing skills ? you?re an email craftsman in particular

? Your interpersonal skills are brilliant and you?re confident and professional when dealing with high profile clients

? You?re an organisational ninja and your time management skills are well-honed

? You genuinely enjoy working as part of a team ? but you won?t throw your toys out the pram if asked to work independently on a project

? You?re enthusiastic, resourceful, and capable of using your own initiative

? Your eye for detail would rival a CSI?s

? You?re ambitious and aspire to do great things (ideally in the work setting but we?re cool if you?re planning to solve global warming)

Skills required

? A good working knowledge of Microsoft Outlook, PowerPoint and Word.

? A good working knowledge of YouTube, Facebook, Twitter and LinkedIn.

Your education

? We?d love to see candidates with an impressive educational background and qualifications/degrees would certainly impress. Even more important though, is your enthusiasm for the industry and a keen willingness to learn.

Your next step

If you feel like this description floats your boat/tickles your pickle/cocas your cola, and you want to join a company where your talents will be recognised, cultivated and rewarded then we want to hear from you.

?

Source: http://www.virtualstudio.tv/blog/post/135-account-executive-job-available-at-virtualstudiotv-in-cambridge

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HEALTH AND FITNESS: Exercise and breast cancer - The Daily Mile

Many local and national organizations are promoting breast cancer awareness, sharing information about the disease and celebrating survivors as a part of Breast Cancer Awareness month. These are all worthy goals that deserve our full attention and support.

Each year more than 200,000 women are diagnosed with breast cancer, and 40,000 die from this disease. Between 20 to 30 percent of cases occur in women who have a family history of breast cancer. A woman with a first-degree relative (mother, sister or daughter) who has had breast cancer has nearly twice the risk of being diagnosed herself. However, most women who are diagnosed with breast cancer have no family history, so there are other factors that can increase or decrease the risk. Among these is regular exercise.

Regular activity and exercise can lower breast cancer risk by as much as 30 percent, according to a recent study of more than 3,000 women. The intensity of the activity didn?t seem to matter, so participation in light activity such as housework and gardening was as effective as walking. What did matter was the amount of time spent being active. Women who reported even low amounts of activity showed a 6 percent reduction in breast cancer risk, but the greatest benefits was seem in women who were active for more than 10 hours per week.

Women who exercise regularly also have a lower chance of recurrence of breast cancer. As many as 1 in 5 of breast cancer survivors experience a recurrence within 10 years. Even relatively low levels of exercise can reduce the risk by 25 percent, but women who are very active have a greater reduction in the recurrence of breast cancer. The amount of exercise needed to realize these benefits is equivalent to 45 to 60 minutes of brisk walking five days per week.

Exercise is effective for reducing breast cancer risk because it lowers levels of the hormone estrogen. This is important because estrogen is linked with the majority of breast cancers and is especially relevant for women with estrogen receptor-positive cancers.

Exercise can also reduce the risk of breast cancer by helping with weight control. Excess body fat increases levels of estrogen, resulting in a higher risk of breast cancer diagnosis and recurrence. Regular physical activity is essential for losing weight and keeping it off. Exercise can also help reduce the increased risk of breast cancer that comes with weight gain, something that is common as women get older.

Women who have been active their whole lives have the lowest risk of breast cancer, but it is never too late to start. Women who exercise also tend to handle breast cancer treatment better than women who aren?t active. In fact, post-cancer exercise programs are becoming more common as a way to help women recover from cancer treatment and prevent recurrence.

Other lifestyle changes that can reduce the risk of breast cancer include maintaining a healthy body weight, consuming alcohol in moderation, not smoking and eating a diet rich in fruits and vegetables. The good news is that these changes also reduce the risk of other cancers, cardiovascular disease and most other chronic diseases.

Brian Parr, Ph.D., is an associate professor in the Department of Exercise and Sports Science at USC Aiken where he teaches courses in exercise physiology, nutrition and health behavior. He is a member of the American College of Sports Medicine and is an ACSM certified clinical exercise specialist; his research focuses on physical activity in weight management and the impact of the environment on activity and diet. Parr lives in Aiken with his wife, Laura, and sons Noah, Owen and Simon.

Fitness and Exercise ? Google News

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Source: http://www.thedailymile.com/archives/2560

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Grade 3 - Teaching Jobs in Canada - powered by Education ...

Clear Water Academy is accepting applications for a full time Grade 3 teacher to start effective October 9, 2012.
The assignment will include all subjects at the Grade 3 level and homeroom responsibilities. A knowledge of or experience with balanced literacy would be beneficial.

A Catholic candidate is sought.

Clear Water Academy is a Christ centered school and is part of a world-wide network of Catholic schools emphasizing character development, high academics and faith formation. Clear Water Academy provides children with a well- rounded education and instills in them the moral and spiritual foundation that will enable them to live lives of purpose and conviction. The school?s motto is ?Semper Altius? ? Always Higher, and this aspiration commits us to excel in leadership training, in academic excellence, in developing the habit of serving others and most especially in growing with Jesus Christ.

Source: http://jobsearch.educationcanada.com/index.phtml?a=v&j=117717

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